The potency analysis of mesenchymal stromal cells and their extracellular vesicles with a focus on apoptotic bodies
Wang, Jiemin
Wang, Jiemin
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Publication Date
2024-10-01
Type
doctoral thesis
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Abstract
Immunotherapy, including immunostimulation and immunosuppression, has seen significant development in the last ten years. Immunostimulation has been verified as effective in anti-cancer treatment, while immunosuppression is used in the treatment of autoimmune disease and inflammation. Currently, with the update of newly invented simplified isolation methods and the findings of potent triggered immune responses, extracellular vesicle-based immunotherapy is very eye-catching. However, the research on three main types of extracellular vesicles, exosomes, microvesicles and apoptotic bodies, needs to be more balanced. These three subtypes share a certain level of similarity, and at the same time, they have their own properties caused by the different methods of biogenesis. Herein, we summarized the status of immunotherapy based on each kind of vesicle and discuss the possible involved mechanisms, respectively. In conclusion, we highlighted that the immunomodulatory effect of the apoptotic body is clear and strong. Apoptotic bodies have an excellent potential in immunosuppressive and anti-inflammatory therapies.
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Publisher
University of Galway
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Attribution-NonCommercial-NoDerivatives 4.0 International