Publication

Association between the 4 bp proinsulin gene insertion polymorphism (ivs-69) and body composition in black south african women

Berman, Peter
Collins, Malcolm
Baumgarten, Ingrid
Seoighe, Cathal
Jennings, Courtney L.
Joffe, Yael
Lambert, Estelle V.
Levitt, Naomi S.
Faulenbach, Mirjam V.
Kahn, Steven E.
... show 1 more
Repository DOI
Publication Date
2009-02-26
Type
Article
Downloads
Citation
Berman, Peter; Collins, Malcolm; Baumgarten, Ingrid; Seoighe, Cathal; Jennings, Courtney L. Joffe, Yael; Lambert, Estelle V.; Levitt, Naomi S.; Faulenbach, Mirjam V.; Kahn, Steven E.; Goedecke, Julia H. (2009). Association between the 4 bp proinsulin gene insertion polymorphism (ivs-69) and body composition in black south african women. Obesity 17 (6), 1298-1300
Abstract
The objective of the study was to examine the association between a functional 4 bp proinsulin gene insertion polymorphism (IVS-69), fasting insulin concentrations, and body composition in black South African women. Body composition, body fat distribution, fasting glucose and insulin concentrations, and IVS-69 genotype were measured in 115 normal-weight (BMI < 25 kg/ m(2)) and 138 obese (BMI >= 30 kg/m(2)) premenopausal women. The frequency of the insertion allele was significantly higher in the class 2 obese (BMI >= 35kg/m(2)) compared with the normal-weight group (P = 0.029). Obese subjects with the insertion allele had greater fat mass (42.3 +/- 0.9 vs. 38.9 +/- 0.9 kg, P = 0.034) and fat-free soft tissue mass (47.4 +/- 0.6 vs. 45.1 +/- 0.6 kg, P = 0.014), and more abdominal subcutaneous adipose tissue (SAT, 595 +/- 17 vs. 531 +/- 17 cm(2), P = 0.025) but not visceral fat (P = 0.739), than obese homozygotes for the wild-type allele. Only SAT was greater in normal-weight subjects with the insertion allele (P = 0.048). There were no differences in fasting insulin or glucose levels between subjects with the insertion allele or homozygotes for the wild-type allele in the normal-weight or obese groups. In conclusion, the 4 bp proinsulin gene insertion allele is associated with extreme obesity, reflected by greater fat-free soft tissue mass and fat mass, particularly SAT, in obese black South African women.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
10.1038/oby.2009.40
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland