COHESION core outcomes in neonatal encephalopathy

Quirke, Fiona
Neonatal encephalopathy is a complex neurological syndrome in newborn infants characterised by depression in tone and consciousness, impaired reflexes, and often seizures. The main subtype of neonatal encephalopathy is hypoxic-ischemic encephalopathy (HIE), caused by a lack of oxygen in the blood reaching the brain and other organs of the body. Therapeutic hypothermia is commonly used to treat HIE in high-income countries, showing evidence of reducing the risk of death and improving outcomes such as neurodevelopmental disability. However, the beneficial effects of therapeutic hypothermia were not replicated in low- to middle-income countries, instead leading to increased death and adverse events in infants. New treatments are now being investigated in randomised trials for the treatment of neonatal encephalopathy. However, researchers cannot compare the findings of trials because different outcomes are measured and reported. One way to minimise the heterogeneity in outcomes reported is to develop a core outcome set (COS). A core outcome set is a standardised set of outcomes agreed by key stakeholders that should be measured and reported in all studies for a health condition as a minimum. The work presented in this thesis (The COHESION Study) aims to develop a COS for interventions for the treatment of neonatal encephalopathy
Health Research Board
NUI Galway
Publisher DOI
Attribution-NonCommercial-NoDerivs 3.0 Ireland