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Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder

Savitz, Jonathan
; 
Nugent, Allison C.
; 
Cannon, Dara M.
; 
Carlson, Paul J.
; 
Davis, Rebecca
; 
Neumeister, Alexander
; 
Rallis-Frutos, Denise
; 
Fromm, Steve
; 
Herscovitch, Peter
; 
Drevets, Wayne C.
Repository DOI
Publication Date
2012-03-08
Keywords
medial prefrontal cortex, positron-emission-tomography, anterior cingulate cortex, default-mode network, painful stimulation, hippocampal volume, glucose-metabolism, bipolar disorder, brain activation, cortisol-levels
Type
Article
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Citation
Savitz, Jonathan; Nugent, Allison C. Cannon, Dara M.; Carlson, Paul J.; Davis, Rebecca; Neumeister, Alexander; Rallis-Frutos, Denise; Fromm, Steve; Herscovitch, Peter; Drevets, Wayne C. (2012). Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder. Scientific Reports 2 ,
Abstract
Individuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [O-15]-H2O positron emission tomography we assessed whether the regional cerebral blood flow (rCBF) response to arterial cannulation differed between patients with MDD and healthy controls (HCs). Fifty-one MDDpatients and 62 HCs were scanned following arterial cannulation and 15MDDpatients and 17 HCs were scanned without arterial cannulation. A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD. A whole brain analysis showed increased rCBF of the right post-central gyrus, left temporopolar cortex, and right amygdala during arterial cannulation in MDD patients. The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.
Funder
Publisher
Springer Nature
Publisher DOI
10.1038/srep00308
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)