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An evaluation of preoperative ca 15-3 measurement in primary breast carcinoma

O'Hanlon, DM
; 
Kerin, MJ
; 
Kent, P
; 
Maher, D
; 
Grimes, H
; 
Given, HF
Repository DOI
Publication Date
1995-06-01
Keywords
breast neoplasia, ca 15-3, tumor marker, monoclonal-antibodies, cancer patients, antigen levels, ca15-3, tumors, df3
Type
Article
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Citation
O'Hanlon, DM; Kerin, MJ; Kent, P; Maher, D; Grimes, H; Given, HF (1995). An evaluation of preoperative ca 15-3 measurement in primary breast carcinoma. British Journal of Cancer 71 (6), 1288-1291
Abstract
In this study of 500 patients with breast carcinoma, we have prospectively assessed the role of preoperative CA 15-3 as a marker of disease burden over a 7 year period. CA 15-3 levels at presentation correlate with stage of disease, tumour size, lymph node status, the presence of metastases and lymphocyte infiltration into the tumour. CA 15-3 alone is not an independent prognostic indicator, although a serum level of > 40 U ml(-1) has a positive predictive value of 83% for the presence of advanced disease. We recommend the routine use of this marker in the preoperative assessment of primary breast carcinoma.
Funder
Publisher
Springer Nature
Publisher DOI
10.1038/bjc.1995.249
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (1)