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Dna repair: the importance of phosphorylating histone h2ax

Lowndes, Noel F.
; 
Toh, Geraldine W.-L.
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http://hdl.handle.net/10379/9450
 https://doi.org/10.13025/23434
Publication Date
2005-02-01
Keywords
double-strand breaks, sister-chromatid cohesion, in-vivo, recruitment, damage, recombination, complexes, proteins, sites
Type
journal article
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Citation
Lowndes, Noel F. Toh, Geraldine W.-L. (2005). Dna repair: the importance of phosphorylating histone h2ax. Current Biology 15 (3), R99-R102
Abstract
How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.
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Elsevier BV
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Externally hosted open access publications with University of Galway authors (1)