Publication

Advances in mesenchymal stem cell-mediated gene therapy for cancer

Dwyer, Róisín M.
; 
Khan, Sonja
; 
Barry, Frank P
; 
O'Brien, Timothy
; 
Kerin, Michael J
Repository DOI
Publication Date
2010-01-01
Keywords
marrow stromal cells, growth in-vivo, functional chemokine receptors, bone-marrow, tumor-growth, targeted-delivery, progenitor cells, oncolytic adenoviruses, intracranial glioma, promoting migration
Type
Article
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Citation
Dwyer, Roisin M; Khan, Sonja; Barry, Frank P; O'Brien, Timothy; Kerin, Michael J (2010). Advances in mesenchymal stem cell-mediated gene therapy for cancer. Stem Cell Research & Therapy 1 ,
Abstract
Mesenchymal stem cells have a natural tropism for tumours and their metastases, and are also considered immunoprivileged. This remarkable combination of properties has formed the basis for many studies investigating their potential as tumour-specific delivery vehicles for suicide genes, oncolytic viruses and secreted therapeutic proteins. The aim of the present review is to discuss the range of approaches that have been used to exploit the tumour-homing capacity of mesenchymal stem cells for gene delivery, and to highlight advances required to realize the full potential of this promising approach.
Funder
Publisher
Springer Nature
Publisher DOI
10.1186/scrt25
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)