Epicardial pulsed field ablation of ganglionated plexi: Computational and pre-clinical evaluation of a bipolar sub-xiphoid catheter for the treatment of atrial fibrillation
O’Brien, Barry Reilly, John Coffey, Ken González-Suárez, Ana Buchta, Piotr Buszman, Piotr P. Lukasik, Karolina Tri, Jason van Zyl, Martin Asirvatham, Samuel
O’Brien, Barry
Reilly, John
Coffey, Ken
González-Suárez, Ana
Buchta, Piotr
Buszman, Piotr P.
Lukasik, Karolina
Tri, Jason
van Zyl, Martin
Asirvatham, Samuel
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Publication Date
2023-12-24
Type
Article
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O’Brien, Barry, Reilly, John, Coffey, Ken, González-Suárez, Ana, Buchta, Piotr, Buszman, Piotr P., Buszman, Piotr P., Lukasik, Karolina, Tri, Jason, van Zyl, Martin, Asirvatham, Samuel. (2024). Epicardial Pulsed Field Ablation of Ganglionated Plexi: Computational and Pre-Clinical Evaluation of a Bipolar Sub-Xiphoid Catheter for the Treatment of Atrial Fibrillation. Bioengineering, 11(1), 18, https://doi.org/10.3390/bioengineering11010018
Abstract
Epicardial pulsed field ablation (PFA) of ganglionated plexi (GPs) is being explored as a potential treatment for atrial fibrillation. Initial work using open-chest access with a monopolar ablation device has been completed. This study describes the early development work for a device that can be used with subxiphoid access and deliver bipolar ablation pulses. Electric field computational models have been used for the initial guidance on pulse parameters. An in vivo assessment of these ablation parameters has been performed in an open-chest canine study, while subxiphoid access and navigation of the device has been demonstrated in a porcine model. Results from this acute study have demonstrated the promising potential of this approach.
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Publisher
MDPI
Publisher DOI
10.3390/bioengineering11010018
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Attribution 4.0 International (CC BY 4.0)