General mechanisms of sensory and neuronal differentiation
Schlosser, Gerhard
Schlosser, Gerhard
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Publication Date
2021-06-18
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book part
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Schlosser, Gerhard. (2021). General mechanisms of sensory and neuronal differentiation In Gerhard Schlosser, Development of sensory and neurosecretory cell types: Vertebrate cranial placodes, Volume 1. Boca Raton: CRC Press.
Abstract
Chapters 5-8 review how the differentiation of various placodal cell types is regulated. The first of these, chapter 5, summarizes common mechanisms regulating the formation of neurons and sensory cells in most placodes. The first section discusses how SoxB1 transcription factors cooperate with other proteins (including HES and Id factors) to keep cells in a proliferating progenitor state, while biasing them towards neuronal or sensory fate. The second section then summarizes how bHLH transcription factors of the Achaete-Scute- (Ascl), Atonal- (Atoh), and Neurogenin- (Neurog) subfamilies initiate the neuronal and sensory differentiation program in a subset of cells while repressing differentiation and maintaining progenitor states in adjacent cells (lateral inhibition). Finally, it is briefly sketched, how bHLH transcription factors cooperate with additional, regionally restricted transcription factors including LIM-type (e.g., Islet1), Paired-type (e.g., Phox2a, Phox2b, DRG11), and POU-type (e.g., Brn3a and Brn3c) homeodomain proteins, COE-type bHLH proteins, Runx proteins and Fox proteins (e.g., FoxG1) in the specification of sensory and neuronal cell types specific for individual placodes.
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CRC Press
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Attribution-NonCommercial-NoDerivatives 4.0 International