Positive symptoms associate with cortical thinning in the superior temporal gyrus via the enigma schizophrenia consortium
Walton, E. Hibar, D. P. van Erp, T. G. M. Potkin, S. G. Roiz-Santiañez, R. Crespo-Facorro, B. Suarez-Pinilla, P. Van Haren, N. E. M. de Zwarte, S. M. C. Kahn, R. S.
Walton, E.
Hibar, D. P.
van Erp, T. G. M.
Potkin, S. G.
Roiz-Santiañez, R.
Crespo-Facorro, B.
Suarez-Pinilla, P.
Van Haren, N. E. M.
de Zwarte, S. M. C.
Kahn, R. S.
Repository DOI
Publication Date
2017-03-29
Keywords
schizophrenia, positive symptoms, superior temporal gyrus, cortical thickness, enigma, freesurfer, mri, scale for the assessment of positive symptoms, positive and negative syndrome scale, 1st episode schizophrenia, auditory verbal hallucinations, bipolar disorder, cerebral-cortex, 1st-episode schizophrenia, planum temporale, thickness, psychosis, metaanalysis, comprehension
Type
Article
Downloads
Citation
Walton, E. Hibar, D. P.; van Erp, T. G. M.; Potkin, S. G.; Roiz-Santiañez, R.; Crespo-Facorro, B.; Suarez-Pinilla, P.; Van Haren, N. E. M.; de Zwarte, S. M. C.; Kahn, R. S.; Cahn, W.; Doan, N. T.; Jørgensen, K. N.; Gurholt, T. P.; Agartz, I.; Andreassen, O. A.; Westlye, L. T.; Melle, I.; Berg, A. O.; Mørch-Johnsen, L.; Faerden, A.; Flyckt, L.; Fatouros-Bergman, H.; Jönsson, E. G.; Hashimoto, R.; Yamamori, H.; Fukunaga, M.; Preda, A.; De Rossi, P.; Piras, F.; Banaj, N.; Ciullo, V.; Spalletta, G.; Gur, R. E.; Gur, R. C.; Wolf, D. H; Satterthwaite, T. D.; Beard, L. M.; Sommer, I. E.; Koops, S.; Gruber, O.; Richter, A.; Krämer, B.; Kelly, S.; Donohoe, G.; McDonald, C.; Cannon, D. M.; Corvin, A.; Gill, M.; Di Giorgio, A.; Bertolino, A.; Lawrie, S.; Nickson, T.; Whalley, H. C.; Neilson, E.; Calhoun, V. D.; Thompson, P. M.; Turner, J. A.; Ehrlich, S.; , (2017). Positive symptoms associate with cortical thinning in the superior temporal gyrus via the enigma schizophrenia consortium. Acta Psychiatrica Scandinavica 135 (5), 439-447
Abstract
ObjectiveBased on the role of the superior temporal gyrus (STG) in auditory processing, language comprehension and self-monitoring, this study aimed to investigate the relationship between STG cortical thickness and positive symptom severity in schizophrenia. MethodThis prospective meta-analysis includes data from 1987 individuals with schizophrenia collected at seventeen centres around the world that contribute to the ENIGMA Schizophrenia Working Group. STG thickness measures were extracted from T1-weighted brain scans using FreeSurfer. The study performed a meta-analysis of effect sizes across sites generated by a model predicting left or right STG thickness with a positive symptom severity score (harmonized SAPS or PANSS-positive scores), while controlling for age, sex and site. Secondary models investigated relationships between antipsychotic medication, duration of illness, overall illness severity, handedness and STG thickness. ResultsPositive symptom severity was negatively related to STG thickness in both hemispheres (left: (std) = -0.052; P = 0.021; right: (std) = -0.073; P = 0.001) when statistically controlling for age, sex and site. This effect remained stable in models including duration of illness, antipsychotic medication or handedness. ConclusionOur findings further underline the important role of the STG in hallmark symptoms in schizophrenia. These findings can assist in advancing insight into symptom-relevant pathophysiological mechanisms in schizophrenia.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
10.1111/acps.12718
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland