Impact of histology region size on measured dielectric properties of biological tissues
Porter, Emily La Gioia, Alessandra O'Halloran, Martin
Porter, Emily
La Gioia, Alessandra
O'Halloran, Martin
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Repository DOI
Publication Date
2017-05-22
Type
Conference Paper
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Citation
Porter, Emily, La Gioia, Alessandra, & O'Halloran, Martin. (2017). Impact of histology region size on measured dielectric properties of biological tissues Paper presented at the 38th Progress In Electromagnetics Research Symposium (Spring PIERS), Saint Petersburg, Russia, 22-25 May, doi:10.1109/PIERS.2017.8262349
Abstract
Accurate knowledge of the dielectric properties of biological tissues is necessary for the design and development of electromagnetic medical technologies. Both electromagnetic diagnostic and therapeutic techniques depend heavily on the dielectric properties of the tissues in the region of interest. These properties quantify the accuracy and efficacy of systems, and enable realistic modelling and simulation prior to clinical evaluation. Despite these strong needs, the dielectric properties reported in the literature have suffered from significant inconsistencies. These inconsistencies have mainly been attributed to clinical confounders that have not historically been well-controlled. In this work, the sensing depth of the dielectric probe, a key clinical confounder, is investigated using heterogenous biological samples composed of porcine muscle and fat. Complex heterogeneous samples can contain several different types of tissues, which are identified through histology. When measuring the dielectric properties, it is crucial to know which tissues contribute to the measurements. In order to achieve this, a histology region is used, which enables correspondence between complex tissue samples and the measured dielectric properties. The histology region is given by the sensing depth in the longitudinal direction, and the sensing radius in the radial direction. We perform dielectric measurements on heterogenous samples and calculate the sensing depth of the dielectric probe for this measurement scenario. We then examine how errors in the assumed sensing depth value affect quantification of the tissue composition. This study demonstrates that the sensing depth, and thus the histology region, has a significant impact on how we interpret the dielectric properties of a sample, indicating that this region must be defined and measured with extreme care. With an improved understanding of these parameters, more accurate and repeatable dielectric measurements will be possible, thus facilitating the development of electromagnetic medical devices.
Publisher
Institute of Electrical and Electronics Engineers
Publisher DOI
10.1109/PIERS.2017.8262349
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland