Caspases as therapeutic targets
Howley, B. Fearnhead, H.O.
Howley, B.
Fearnhead, H.O.
Repository DOI
Publication Date
2008-09-01
Keywords
apoptosis, inhibitors, inflammation, transplant, interleukin-1-beta converting-enzyme, nf-kappa-b, familial mediterranean fever, ischemia-reperfusion injury, liver preservation injury, domain-containing protein, alzheimers-disease brain, programmed cell-death, gamma-inducing factor, mutant huntingtin
Type
Article
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Citation
Howley, B. Fearnhead, H.O. (2008). Caspases as therapeutic targets. Journal of Cellular and Molecular Medicine 12 (5), 1502-1516
Abstract
The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; deregulation of their activation or expression can lead to the development of conditions such as neurodegenerative and autoinflammatory disorders. This review details the different caspase-associated disorders while focusing on caspase-1 inhibition as a potential therapeutic strategy. Problems facing the development of effective and safe caspase therapeutics will also be addressed.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
10.1111/j.1582-4934.2008.00292.x
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland