The use of the biodesign innovation process to identify an unmet clinical need in mitral valve regurgitation
Flannery, Art
Flannery, Art
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Publication Date
2024-06-24
Type
master thesis
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Abstract
Mitral Valve Regurgitation is a left sided heart condition where the Mitral Valve fails to prevent blood flow from the left ventricle returning into the Left Atrium during ventricular systole (when the left ventricle pumps blood from the heart into the arterial system).
Mitral Valve Regurgitation can affect patients in different ways. Non-symptomatic patients may have no impact on their ability to carry out day to day activities, but this is a progressive disease and patients can become symptomatic. Once symptomatic, patients are impacted initially though a reduction in the ability to carry out day to day activities (shortness of breath and fatigue) before eventually progressing to more serious conditions like pulmonary oedema and eventually heart failure.
For half of symptomatic patients impacted surgery is not an option with limited potential for non-surgical interventions to rectify the issue. As 10% of the population 75yrs or older have some level of significant regurgitation the lack of non-surgical options is a major issue for patients and has a significant impact on mortality.
There is a very significant need to develop a transcatheter solution to provide a treatment pathway for these patients who need such a solution.
Through this thesis I will describe the stages of BioInnovate process which were followed to identify unmet clinical needs in the cardiology field and to identify Mitral Valve Regurgitation as an unmet need. The thesis will then follow through the BioInnovate process describing the steps involved in generating a novel solution to Mitral Valve Regurgitation to address this unmet clinical need.
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University of Galway
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Attribution-NonCommercial-NoDerivatives 4.0 International