Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs.
Wernecke, Martina Mullen, Ciara Sharma, Vimla Morrison, John Barry, Thomas Maher, Majella Smith, Terry
Wernecke, Martina
Mullen, Ciara
Sharma, Vimla
Morrison, John
Barry, Thomas
Maher, Majella
Smith, Terry
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2009
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Wernecke M, Mullen C, Sharma V, Morrison J, Barry T, Maher M, Smith T (2009) 'Evaluation of a novel real-time PCR test based on the ssrA gene for the identification of group B streptococci in vaginal swabs'. BMC Infectious Diseases, 9 .
Abstract
Despite the implementation of prevention guidelines, early-onset group B streptococci (GBS) disease remains a cause of neonatal morbidity and mortality worldwide. Strategies to identify women who are at risk of transmitting GBS to their infant and the administration of intrapartum antibiotics have greatly reduced the incidence of neonatal GBS disease. However, there is a requirement for a rapid diagnostic test for GBS that can be carried out in a labour ward setting especially for women whose GBS colonisation status is unknown at the time of delivery. We report the design and evaluation of a real-time PCR test (RiboSEQ GBS test) for the identification of GBS in vaginal swabs from pregnant women.
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Attribution-NonCommercial-NoDerivs 3.0 Ireland