Publication

Biopolymer-based nanoparticles for cystic fibrosis lung gene therapy studies

Fernández Fernández, Elena
Santos-Carballal, Beatriz
de Santi, Chiara
Ramsey, Joanne
MacLoughlin, Ronan
Cryan, Sally-Ann
Greene, Catherine
Citation
Fernández Fernández, Elena; Santos-Carballal, Beatriz; de Santi, Chiara; Ramsey, Joanne; MacLoughlin, Ronan; Cryan, Sally-Ann; Greene, Catherine (2018). Biopolymer-based nanoparticles for cystic fibrosis lung gene therapy studies. Materials 11 (1),
Abstract
Lung gene therapy for cystic fibrosis disease has not been successful due to several challenges such as the absence of an appropriate vector. Therefore, optimal delivery of emerging therapeutics to airway epithelial cells demands suitable non-viral systems. In this work, we describe the formulation and the physicochemical investigation of biocompatible and biodegradable polymeric nanoparticles (NPs), including PLGA and chitosan (animal and non-animal), as novel methods for the safe and efficient delivery of CFTR-specific locked nucleic acids (LNAs).
Funder
Publisher
MDPI AG
Publisher DOI
10.3390/ma11010122
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland