Publication

The major autolysin is redundant forstaphylococcus aureususa300 lac je2 virulence in a murine device-related infection model

McCarthy, Hannah
Waters, Elaine M.
Bose, Jeffrey L.
Foster, Simon
Bayles, Kenneth W.
O'Neill, Eoghan
Fey, Paul D.
O'Gara, James P
Citation
McCarthy, Hannah; Waters, Elaine M. Bose, Jeffrey L.; Foster, Simon; Bayles, Kenneth W.; O'Neill, Eoghan; Fey, Paul D.; O'Gara, James P (2016). The major autolysin is redundant forstaphylococcus aureususa300 lac je2 virulence in a murine device-related infection model. FEMS Microbiology Letters 363 (9),
Abstract
The major Staphylococcus aureus autolysin, Atl, has been implicated in attachment to surfaces and release of extracellular DNA during biofilm formation under laboratory conditions. Consistent with this, polyclonal antibodies to the amidase and glucosaminidase domains of Atl inhibited in vitro biofilm formation. However, in a murine model of device-related infection the community-associated S. aureus strain USA300 LAC JE2 established a successful infection in the absence of atl. These data indicate that Atl activity is not required for biofilm production in this infection model and reveal the importance of characterizing the contribution of biofilm phenotypes to virulence under in vivo conditions.
Funder
Publisher
Oxford University Press (OUP)
Publisher DOI
10.1093/femsle/fnw087
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland