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In vitro models for assessing therapeutic angiogenesis

Sanz-Nogués, Clara
; 
O'Brien, Timothy
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Identifiers
http://hdl.handle.net/10379/16780
 https://doi.org/10.13025/21677
Publication Date
2016-06-01
Keywords
neovascularization, therapeutic angiogenesis, arteriogenesis, cell therapy product, in vitro models, in vitro microvessels, mesenchymal stem/stromal cells, endothelial cells, capillary-like structures
Type
Article
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Citation
Sanz-Nogués, Clara, & O’Brien, Timothy. (2016). In vitro models for assessing therapeutic angiogenesis. Drug Discovery Today, 21(9), 1495-1503. doi:https://doi.org/10.1016/j.drudis.2016.05.016
Abstract
Arterial obstruction leading to ischemia causes a reduction of oxygen and nutrient supply to distal tissues. The physiological response to tissue ischemia triggers a cascade of events that results in the development of accessory vasculature to increase local tissue perfusion and to salvage tissue. However, this adaptive mechanism of repair is suboptimal in some patients. Therapeutic angiogenesis aims to stimulate new blood vessel formation via the local administration of proangiogenic agents or cell therapy products (CTPs). In this review, we provide a summary of the current understanding of in vitro models for assessing the angiogenic potential of a product.
Funder
Science Foundation Ireland
Publisher
Elsevier
Publisher DOI
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Regenerative Medicine Institute (Scholarly Articles)