Oral loratadine in the management of G-CSF induced bone pain: a pilot study
Duggan, Caitriona Murphy, Louise Costello, Vicky O Leary, Eilis Dien Yousif, Ala Blazcova, Silvie Dowling, Maura
Duggan, Caitriona
Murphy, Louise
Costello, Vicky
O Leary, Eilis
Dien Yousif, Ala
Blazcova, Silvie
Dowling, Maura
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Publication Date
2019-02-27
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Article
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Duggan, Caitriona, Murphy, Louise, Costello, Vicky, Leary, Eilis O, Yousif, Ala Dien, Blazkova, Silvie, & Dowling, Maura. (2019). Oral loratadine in the management of G-CSF-induced bone pain: a pilot study. British Journal of Nursing, 28(4), S4-S11. doi: 10.12968/bjon.2019.28.4.S4
Abstract
This pilot study aimed to ascertain if bone pain induced by granulocyte-colony stimulating factors (G-CSFs) can be alleviated or eliminated by oral antihistamine loratadine. Twelve patients with cancer receiving chemotherapy were included in the study. Daily pain increased between before treatment started and after cycle 1 in all patients. All 12 participants were started on loratadine on cycle 2; three patients were taking pain medications in addition to this as needed, which were ibruprofen (n=1) or tramadol (n=2). Pain decreased towards the later cycles after patients were started on loratadine in cycle 2, with the exception of one patient who also took tramadol as needed in cycle 3. Oral loratadine was found to be associated with pain reduction in patients with cancer receiving G-CSFs.
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Publisher
Mark Allen Healthcare
Publisher DOI
10.12968/bjon.2019.28.4.S4
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Attribution-NonCommercial-NoDerivs 3.0 Ireland