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Double-edged sword: a p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury

McNicholas, Bairbre A.
; 
Griffin, Matthew D.
Repository DOI
Publication Date
2012-06-01
Keywords
renal ischemia-reperfusion
Type
Article
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Citation
McNicholas, Bairbre A. Griffin, Matthew D. (2012). Double-edged sword: a p53 regulator mediates both harmful and beneficial effects in experimental acute kidney injury. Kidney International 81 (12), 1161-1164
Abstract
Acute kidney injury triggers activation of innate immune responses and of proapoptotic programs such as the p53 pathway. Mulay et al. examine the effects of blocking murine double minute-2 (mdm2), a negative regulator of p53, using a novel chemotherapeutic agent, nutlin-3a, in mouse ischemia-reperfusion injury. Their results indicate that mdm2 promotes renal regeneration by limiting p53-mediated apoptosis but also enhances early inflammation by facilitating DNA binding of nuclear factor-kappa B independently of p53.
Funder
Publisher
Elsevier BV
Publisher DOI
10.1038/ki.2012.36
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (2)