Migrastatin analogues inhibit canine mammary cancer cell migration and invasion.
Lo Re, Daniele ; Murphy, Paul V.
Lo Re, Daniele
Murphy, Paul V.
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Identifiers
http://hdl.handle.net/10379/4324
https://doi.org/10.13025/14816
https://doi.org/10.13025/14816
Repository DOI
Publication Date
2013-10-08
Type
Article
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Citation
Majchrzak K, Lo Re D, Gajewska M, Bulkowska M, Homa A, PawŠowski K, Motyl T, Murphy PV, Król M (2013) 'Migrastatin analogues inhibit canine mammary cancer cell migration and invasion'. Plos One, 8 (10).
Abstract
Cancer spread to other organs is the main cause of death of oncological patients. Migration of cancer cells from a primary tumour is the crucial step in the complex process of metastasis, therefore blocking this process is currently the main treatment strategy. Metastasis inhibitors derived from natural products, such as, migrastatin, are very promising anticancer agents. Thus, the aim of our study was to investigate the effect of six migrastatin analogues (MGSTA-1 to 6) on migration and invasion of canine mammary adenocarcinoma cell lines isolated from primary tumours and their metastases to the lungs. Canine mammary tumours constitute a valuable tool for studying multiple aspect of human cancer.
Funder
Publisher
PlosOne
Publisher DOI
10.1371/journal.pone.0076789
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland