Sulfated steroid–amino acid conjugates from the irish marine sponge polymastia boletiformis
Smyrniotopoulos, Vangelis Rae, Margaret Soldatou, Sylvia Ding, Yuanqing Wolff, Carsten McCormack, Grace Coleman, Christina Ferreira, Daneel Tasdemir, Deniz
Smyrniotopoulos, Vangelis
Rae, Margaret
Soldatou, Sylvia
Ding, Yuanqing
Wolff, Carsten
McCormack, Grace
Coleman, Christina
Ferreira, Daneel
Tasdemir, Deniz
Repository DOI
Publication Date
2015-03-24
Type
Article
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Citation
Smyrniotopoulos, Vangelis; Rae, Margaret; Soldatou, Sylvia; Ding, Yuanqing; Wolff, Carsten; McCormack, Grace; Coleman, Christina; Ferreira, Daneel; Tasdemir, Deniz (2015). Sulfated steroid–amino acid conjugates from the irish marine sponge polymastia boletiformis. Marine Drugs 13 (4), 1632-1646
Abstract
Antifungal bioactivity-guided fractionation of the organic extract of the sponge Polymastia boletiformis, collected from the west coast of Ireland, led to the isolation of two new sulfated steroid-amino acid conjugates (1 and 2). Extensive 1D and 2D NMR analyses in combination with quantum mechanical calculations of the electronic circular dichroism (ECD) spectra, optical rotation, and C-13 chemical shifts were used to establish the chemical structures of 1 and 2. Both compounds exhibited moderate antifungal activity against Cladosporium cucumerinum, while compound 2 was also active against Candida albicans. Marine natural products containing steroidal and amino acid constituents are extremely rare in nature.
Funder
Publisher
MDPI AG
Publisher DOI
10.3390/md13041632
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland