Publication

The integrated stress response

Pakosā€Zebrucka, Karolina
; 
Koryga, Izabela
; 
Mnich, Katarzyna
; 
Ljujic, Mila
; 
Samali, Afshin
; 
Gorman, Adrienne M.
Repository DOI
Publication Date
2016-09-14
Keywords
activating transcription factor 4, eif2 alpha kinase, eukaryotic translation initiation factor 2 alpha, integrated stress response, endoplasmic-reticulum stress, unfolded-protein response, double-stranded-rna, activating transcription factor-4, initiation-factor 2, factor 2-alpha kinase, asparagine synthetase gene, heme-regulated inhibitor, induced cell-death, factor 4 atf4
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Article
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Citation
Pakosā€Zebrucka, Karolina; Koryga, Izabela; Mnich, Katarzyna; Ljujic, Mila; Samali, Afshin; Gorman, Adrienne M (2016). The integrated stress response. EMBO reports 17 (10), 1374-1395
Abstract
In response to diverse stress stimuli, eukaryotic cells activate a common adaptive pathway, termed the integrated stress response (ISR), to restore cellular homeostasis. The core event in this pathway is the phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2 alpha) by one of four members of the eIF2 alpha kinase family, which leads to a decrease in global protein synthesis and the induction of selected genes, including the transcription factor ATF4, that together promote cellular recovery. The gene expression program activated by the ISR optimizes the cellular response to stress and is dependent on the cellular context, as well as on the nature and intensity of the stress stimuli. Although the ISR is primarily a pro-survival, homeostatic program, exposure to severe stress can drive signaling toward cell death. Here, we review current understanding of the ISR signaling and how it regulates cell fate under diverse types of stress.
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Publisher
EMBO
Publisher DOI
10.15252/embr.201642195
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)