Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling
Gorman, Adrienne M.
Gorman, Adrienne M.
Publication Date
2008-07-10
Keywords
alzheimer's disease (ad), apoptosis, autophagic cell death (acd), autophagy, endoplasmic reticulum (er) stress, excitotoxicity, heat shock proteins (hsps), huntington's disease (hd), ischaemia, parkinson's disease (pd), protein aggregation, ubiquitin-proteasome system (ups), unfolded protein response (upr), endoplasmic-reticulum stress, ubiquitin-proteasome system, focal cerebral-ischemia, cytochrome-c release, amyloid precursor protein, mutant alpha-synuclein, parkinsons-disease, alzheimers-disease, huntingtons-disease, mitochondrial dysfunction
Type
Article
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Citation
Gorman, Adrienne M. (2008). Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. Journal of Cellular and Molecular Medicine 12 (6), 2263-2280
Abstract
Neuronal cell death plays a role in many chronic neurodegenerative diseases with the loss of particular subsets of neurons. The loss of the neurons occurs during a period of many years, which can make the mode(s) of cell death and the initiating factors difficult to determine. In vitro and in vivo models have proved invaluable in this regard, yielding insight into cell death pathways. This review describes the main mechanisms of neuronal cell death, particularly apoptosis, necrosis, excitotoxicity and autophagic cell death, and their role in neurodegenerative diseases such as ischaemia, Alzheimer's, Parkinson's and Huntington's diseases. Crosstalk between these death mechanisms is also discussed. The link between cell death and protein mishandling, including misfolded proteins, impairment of protein degradation, protein aggregation is described and finally, some pro-survival strategies are discussed.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland