Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential
Griffin, Tomás Patrick Islam, Md Nahidul Wall, Deirdre Ferguson, John Griffin, Damian Gerard Griffin, Matthew D. O’Shea, Paula M.
Griffin, Tomás Patrick
Islam, Md Nahidul
Wall, Deirdre
Ferguson, John
Griffin, Damian Gerard
Griffin, Matthew D.
O’Shea, Paula M.
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Publication Date
2019-12-05
Type
Article
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Citation
Griffin, Tomás Patrick, Islam, Md Nahidul, Wall, Deirdre, Ferguson, John, Griffin, Damian Gerard, Griffin, Matthew Dallas, & O’Shea, Paula M. (2019). Plasma dephosphorylated-uncarboxylated Matrix Gla-Protein (dp-ucMGP): reference intervals in Caucasian adults and diabetic kidney disease biomarker potential. Scientific Reports, 9(1), 18452. doi:10.1038/s41598-019-54762-2
Abstract
Recent studies suggest a possible association between dephosphorylated-uncarboxylated MGP (dp-ucMGP) and glomerular filtration rate (GFR). This study aimed to establish normative data in an adult Caucasian population and to explore the potential utility of dp-ucMGP in patients with diabetes mellitus (DM) with and without diabetic kidney disease (DKD). Healthy volunteers (HVs) (cross-sectional study) and participants with DM (prospective cohort study) were recruited. Plasma dp-ucMGP was measured using the IDS®-iSYS Ina Ktif (dp-ucMGP) assay. Of the HVs recruited (n = 208), 67(32.2%) were excluded leaving a reference population of 141(67.8%) metabolically healthy participants with normal kidney function. Plasma dp-ucMGP RIs were
Publisher
Nature Research
Publisher DOI
10.1038/s41598-019-54762-2
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Attribution-NonCommercial-NoDerivs 3.0 Ireland