Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol
Harmon, D. Rozario, C. Lowe, D.
Harmon, D.
Rozario, C.
Lowe, D.
Repository DOI
Publication Date
2003-02-01
Type
Article
Downloads
Citation
Harmon, D. Rozario, C.; Lowe, D. (2003). Nitrous oxide/oxygen mixture and the prevention of pain during injection of propofol. European Journal of Anaesthesiology 20 (2), 158-161
Abstract
Background and objective: The incidence of pain associated with the injection of propofol still remains a problem. This study sought to examine the analgesic effects of inhaled nitrous oxide in oxygen on the prevention of propofol injection pain. Methods: Nitrous oxide in oxygen was compared with a lidocaine (20mg)-propofol mixture and with propofol alone (control) in a prospective, randomized, observer-blinded study. ASA I and 11 patients (n = 135) scheduled for elective surgical procedures were studied. A standard propofol injection technique and scoring system to measure the pain on injection was used. Results: Demographic variables were similar between the study groups. Without analgesia (control) 26 of 45 patients (58%) reported pain on injection compared with 11 of 45 patients (24%) in both the nitrous oxide (95% CI: 14-52%, P = 0.001) and lidocaine groups (95% Cl: 14-52%, P = 0.001). Conclusions: The inhalation of a nitrous oxide/oxygen mixture significantly reduces the incidence of pain during propofol injection. This therapeutic stratagem was as effective as a lidocaine-propofol mixture.
Funder
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
10.1097/00003643-200302000-00014
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland