53bp1: function and mechanisms of focal recruitment
FitzGerald, Jennifer E. Grenon, Muriel Lowndes, Noel F.
FitzGerald, Jennifer E.
Grenon, Muriel
Lowndes, Noel F.
Repository DOI
Publication Date
2009-08-01
Keywords
dot1, histone 2ax (h2ax), histone methylation, mediator of DNA-damage checkpoint 1 (mdc1), p53-binding protein 1 (53bp1), rad9, DNA-damage-response, double-strand breaks, class-switch recombination, checkpoint protein crb2, histone h2ax, saccharomyces-cerevisiae, budding yeast, genomic instability, cellular-response, ubiquitin ligase
Type
Article
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Citation
FitzGerald, Jennifer E. Grenon, Muriel; Lowndes, Noel F. (2009). 53bp1: function and mechanisms of focal recruitment. Biochemical Society Transactions 37 , 897-904
Abstract
53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-damage response, and is recruited to nuclear structures termed foci following genotoxic insult. In the present paper, we review the functions of S3BP1 in DNA-damage checkpoint activation and DNA repair, and the mechanisms of its recruitment and activation following DNA damage. We focus in particular on the role of covalent histone modifications in this process.
Funder
Publisher
Portland Press Ltd.
Publisher DOI
10.1042/bst0370897
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland