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Mononuclear phagocyte depletion strategies in models of acute kidney disease: what are they trying to tell us?

Griffin, Matthew D.
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Publication Date
2012-10-01
Keywords
dendritic cells, injury, macrophages, progression, contribute
Type
Article
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Citation
Griffin, Matthew D. (2012). Mononuclear phagocyte depletion strategies in models of acute kidney disease: what are they trying to tell us?. Kidney International 82 (8), 835-837
Abstract
Mononuclear phagocytes (macrophages, dendritic cells, and monocytes) play a complex role in kidney disease. Techniques for selectively depleting them in rodents have made important contributions but have also generated some contradictory results. Ferenbach et al. report that two widely used mononuclear phagocyte depletion techniques differentially affect early severity of renal ischemia/reperfusion injury and provide evidence that this may be due to a residual, protective subset that persists in the kidney after one of the two techniques. Kidney International (2012) 82, 835-837. doi:10.1038/ki.2012.164
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Publisher
Elsevier BV
Publisher DOI
10.1038/ki.2012.164
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (2)