A Highly Effective Gene Delivery Vector

Newland, Ben
Tai, Hongyun
Zheng, Yu
Velasco, Diego
Di Luca, Andrea
Howdle, Steven M.
Alexander, Cameron
Wang, Wenxin
Pandit, Abhay
Newland, B., Tai, H., Zheng, Y., Velasco, D., Di Luca, A., Howdle, S. M., et al. A highly effective gene delivery vector - hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP. Chemical Communications, 46(26), 4698-4700.
A hyperbranched 2-(dimethylamino)ethyl methacrylate (DMAEMA) based polymer has been synthesised by a one-pot in situ deactivation enhanced atom transfer radical polymerisation (DE-ATRP); it exhibits much higher transfection ability than linear poly(DMAEMA) and is comparable to the well known branched poly(ethylene imine) (PEI) and the SuperFect dendrimer but with lower cytotoxicity.
The Royal Society of Chemistry
Publisher DOI
Attribution-NonCommercial-NoDerivs 3.0 Ireland