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The relationship between cardiac output and dynamic cerebral autoregulation in humans

Deegan, B. M.
; 
Devine, E. R.
; 
Geraghty, M. C.
; 
Jones, E.
; 
OLaighin, G.
; 
Serrador, J. M.
Repository DOI
Publication Date
2010-08-05
Keywords
cerebral blood flow, echocardiography, transcranial doppler, artery blood velocity, left-ventricular volumes, flow velocity, gender-differences, orthostatic stress, auto-regulation, exercise, pressure, perfusion, echocardiography
Type
Article
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Citation
Deegan, B. M. Devine, E. R.; Geraghty, M. C.; Jones, E.; OLaighin, G.; Serrador, J. M. (2010). The relationship between cardiac output and dynamic cerebral autoregulation in humans. Journal of Applied Physiology 109 (5), 1424-1431
Abstract
Cerebral autoregulation adjusts cerebrovascular resistance in the face of changing perfusion pressures to maintain relatively constant flow. Results from several studies suggest that cardiac output may also play a role. We tested the hypothesis that cerebral blood flow would autoregulate independent of changes in cardiac output. Transient systemic hypotension was induced by thigh-cuff deflation in 19 healthy volunteers (7 women) in both supine and seated positions. Mean arterial pressure (Finapres), cerebral blood flow (transcranial Doppler) in the anterior (ACA) and middle cerebral artery (MCA), beat-by-beat cardiac output (echocardiography), and end-tidal PCO(2) were measured. Autoregulation was assessed using the autoregulatory index (ARI) defined by Tiecks et al. (Tiecks FP, Lam AM, Aaslid R, Newell DW. Stroke 26: 1014-1019, 1995). Cerebral autoregulation was better in the supine position in both the ACA [supine ARI: 5.0 +/- 0.21 (mean +/- SE), seated ARI: 3.9 +/- 0.4, P = 0.01] and MCA (supine ARI: 5.0 +/- 0.2, seated ARI: 3.8 +/- 0.3, P = 0.004). In contrast, cardiac output responses were not different between positions and did not correlate with cerebral blood flow ARIs. In addition, women had better autoregulation in the ACA (P = 0.046), but not the MCA, despite having the same cardiac output response. These data demonstrate cardiac output does not appear to affect the dynamic cerebral autoregulatory response to sudden hypotension in healthy controls, regardless of posture. These results also highlight the importance of considering sex when studying cerebral autoregulation.
Funder
Publisher
American Physiological Society
Publisher DOI
10.1152/japplphysiol.01262.2009
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)