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Defective neutrophil rolling and transmigration in acute uremia

Pindjakova, Jana
; 
Griffin, Matthew D.
Repository DOI
Publication Date
2011-09-01
Keywords
lung injury, inflammation, nephrectomy, infection, adhesion, failure
Type
Article
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Citation
Pindjakova, Jana; Griffin, Matthew D. (2011). Defective neutrophil rolling and transmigration in acute uremia. Kidney International 80 (5), 447-450
Abstract
Circulating neutrophils are essential for innate immunity and undergo rapid, stepwise adhesion to and transmigration through the endothelium following tissue injury and microbial invasion. Neutrophil dysfunction may contribute to morbidity and mortality in acute kidney injury but has not frequently been studied at a mechanistic level. Rossaint et al. provide experimental evidence in mice and humans that acute uremia causes discrete intracellular signaling abnormalities that interfere with specific stages of neutrophil trafficking during inflammation. Kidney International (2011) 80, 447-450. doi:10.1038/ki.2011.169
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Publisher
Elsevier BV
Publisher DOI
10.1038/ki.2011.169
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)