Transcatheter aortic valve replacement in bicuspid aortic valve disease
Mylotte, Darren Lefevre, Thierry Søndergaard, Lars Watanabe, Yusuke Modine, Thomas Dvir, Danny Bosmans, Johan Tchetche, Didier Kornowski, Ran Sinning, Jan-Malte
Mylotte, Darren
Lefevre, Thierry
Søndergaard, Lars
Watanabe, Yusuke
Modine, Thomas
Dvir, Danny
Bosmans, Johan
Tchetche, Didier
Kornowski, Ran
Sinning, Jan-Malte
Repository DOI
Publication Date
2014-12-01
Keywords
aortic stenosis, aortic valve replacement, bicuspid aortic valve, transcatheter aortic valve implantation, transcatheter aortic valve replacement, high-risk patients, paravalvular regurgitation, computed-tomography, heart-valve, implantation, stenosis, outcomes, system, echocardiography, determinants
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Article
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Citation
Mylotte, Darren; Lefevre, Thierry; Søndergaard, Lars; Watanabe, Yusuke; Modine, Thomas; Dvir, Danny; Bosmans, Johan; Tchetche, Didier; Kornowski, Ran; Sinning, Jan-Malte; Thériault-Lauzier, Pascal; O'Sullivan, Crochan J. Barbanti, Marco; Debry, Nicolas; Buithieu, Jean; Codner, Pablo; Dorfmeister, Magdalena; Martucci, Giuseppe; Nickenig, Georg; Wenaweser, Peter; Tamburino, Corrado; Grube, Eberhard; Webb, John G.; Windecker, Stephan; Lange, Ruediger; Piazza, Nicolo (2014). Transcatheter aortic valve replacement in bicuspid aortic valve disease. Journal of the American College of Cardiology 64 (22), 2330-2339
Abstract
BACKGROUND Limited information exists describing the results of transcatheter aortic valve (TAV) replacement in patients with bicuspid aortic valve (BAV) disease (TAV-in-BAV). OBJECTIVES This study sought to evaluate clinical outcomes of a large cohort of patients undergoing TAV-in-BAV. METHODS We retrospectively collected baseline characteristics, procedural data, and clinical follow-up findings from 12 centers in Europe and Canada that had performed TAV-in-BAV. RESULTS A total of 139 patients underwent TAV-in-BAV with the balloon-expandable transcatheter heart valve (THV) (n 48) or self-expandable THV (n 91) systems. Patient mean age and Society of Thoracic Surgeons predicted risk of mortality scores were 78.0 8.9 years and 4.9 3.4%, respectively. BAV stenosis occurred in 65.5%, regurgitation in 0.7%, and mixed disease in 33.8% of patients. Incidence of type 0 BAV was 26.7%; type 1 BAV was 68.3%; and type 2 BAV was 5.0%. Multislice computed tomography (MSCT)-based TAV sizing was used in 63.5% of patients (77.1% balloon-expandable THV vs. 56.0% self-expandable THV, p 0.02). Procedural mortality was 3.6%, with TAV embolization in 2.2% and conversion to surgery in 2.2%. The mean aortic gradient decreased from 48.7 16.5 mm Hg to 11.4 9.9 mm Hg (p < 0.0001). Post-implantation aortic regurgitation (AR) grade $ 2 occurred in 28.4% (19.6% balloon-expandable THV vs. 32.2% self-expandable THV, p 0.11) but was prevalent in only 17.4% when MSCT-based TAV sizing was performed (16.7% balloon-expandable THV vs. 17.6% self-expandable THV, p 0.99). MSCT sizing was associated with reduced AR on multivariate analysis (odds ratio [ OR]: 0.19, 95% confidence intervals [ CI]: 0.08 to 0.45; p < 0.0001). Thirty-day device safety, success, and efficacy were noted in 79.1%, 89.9%, and 84.9% of patients, respectively. One-year mortality was 17.5%. Major vascular complications were associated with increased 1-year mortality (OR: 5.66, 95% CI: 1.21 to 26.43; p 0.03). CONCLUSIONS TAV-in-BAV is feasible with encouraging short-and intermediate-term clinical outcomes. Importantly, a high incidence of post-implantation AR is observed, which appears to be mitigated by MSCT-based TAV sizing. Given the suboptimal echocardiographic results, further study is required to evaluate long-term efficacy. (J Am Coll Cardiol 2014; 64: 2330-9) c 2014 by the American College of Cardiology Foundation.
Funder
Publisher
Elsevier BV
Publisher DOI
10.1016/j.jacc.2014.09.039
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland