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The past, present and future in scaffold-based tendon treatments

Lomas, A.J.
; 
Ryan, C.N.M.
; 
Sorushanova, A.
; 
Shologu, N.
; 
Sideri, A.I.
; 
Tsioli, V.
; 
Fthenakis, G.C.
; 
Tzora, A.
; 
Skoufos, I.
; 
Quinlan, Leo R.
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Publication Date
2015-04
Keywords
Human and equine tendon injury, Tendon cellular and extracellular composition, Tendon healing, Tissue grafts, Biomaterials, Sustained and localised delivery of therapeutics/biologics, ANTERIOR CRUCIATE-LIGAMENT, PLATELET-RICH PLASMA, MESENCHYMAL STEM-CELLS, DIGITAL FLEXOR TENDON, TISSUE ENGINEERING APPLICATIONS, HUMAN ACHILLES-TENDON, MARROW STROMAL CELLS, ROTATOR CUFF REPAIR, GROWTH-FACTOR SUPPLEMENTATION, PROXIMAL SUSPENSORY DESMITIS
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Citation
Lomas, A. J., Ryan, C. N. M., Sorushanova, A., Shologu, N., Sideri, A. I., Tsioli, V. Fthenakis, G. C., Tzora, A., Skoufos, I., Quinlan, L. R., O'Laighin, G., Mullen, A. M., Kelly, J. L., Kearns, S., Biggs, M., Pandit, A. , Zeugolis, D. I. (2015). The past, present and future in scaffold-based tendon treatments. Advanced Drug Delivery Reviews, 84, 257-277. doi: https://doi.org/10.1016/j.addr.2014.11.022
Abstract
Tendon injuries represent a significant clinical burden on healthcare systems worldwide. As the human population ages and the life expectancy increases, tendon injuries will become more prevalent especially among young individuals with long life ahead of them. Advancements in engineering, chemistry and biology have made available an array of three-dimensional scaffold-based intervention strategies, natural or synthetic in origin. Further, functionalisation strategies, based on biophysical, biochemical and biological cues, offer control over cellular functions; localisation and sustained release of therapeutics/biologics; and the ability to positively interact with the host to promote repair and regeneration. Herein, we critically discuss current therapies and emerging technologies that aim to transform tendon treatments in the years to come. (C) 2014 Elsevier B.V. All rights reserved.
Funder
Science Foundation Ireland
EU Framework Programme 7
Publisher
Elsevier
Publisher DOI
10.1016/j.addr.2014.11.022
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Collections
Biomedical Engineering (Scholarly Articles)