Publication

Advances in precision medicine: tailoring individualized therapies

Matchett, Kyle
; 
Lynam-Lennon, Niamh
; 
Watson, R.
; 
Brown, James
Repository DOI
Publication Date
2017-10-25
Keywords
ireland cancer meeting, personalized, pdx, avatar, precision medicine, profiling, xenografts, patient-derived xenografts, prostate-cancer, breast-cancer, tumor xenografts, solid tumors, neuroblastoma, evolution, responses, children, metastasis
Type
Article
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Citation
Matchett, Kyle; Lynam-Lennon, Niamh; Watson, R. Brown, James (2017). Advances in precision medicine: tailoring individualized therapies. Cancers 9 (11),
Abstract
The traditional bench-to-bedside pipeline involves using model systems and patient samples to provide insights into pathways deregulated in cancer. This discovery reveals new biomarkers and therapeutic targets, ultimately stratifying patients and informing cohort-based treatment options. Precision medicine (molecular profiling of individual tumors combined with established clinical-pathological parameters) reveals, in real-time, individual patient's diagnostic and prognostic risk profile, informing tailored and tumor-specific treatment plans. Here we discuss advances in precision medicine presented at the Irish Association for Cancer Research Annual Meeting, highlighting examples where personalized medicine approaches have led to precision discovery in individual tumors, informing customized treatment programs.
Funder
Publisher
MDPI AG
Publisher DOI
10.3390/cancers9110146
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (2)