Vitamin b12-metal conjugates for targeted chemotherapy and diagnosis: current status and future prospects
Pettenuzzo, Andrea Pigot, Rebecca Ronconi, Luca
Pettenuzzo, Andrea
Pigot, Rebecca
Ronconi, Luca
Repository DOI
Publication Date
2017-01-23
Keywords
vitamin b-12, cobalamin, metallodrugs, drug design, medicinal inorganic chemistry targeted chemotherapy, tumor imaging, antitumor agents, imaging agents, transition-metal-complexes, transcobalamin ii receptor, co-releasing molecules, type-1 diabetic mice, mri contrast agents, carbon-monoxide, medicinal applications, labeled vitamin-b12, cobalamin analogs, b-12 trafficking
Type
Article
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Citation
Pettenuzzo, Andrea; Pigot, Rebecca; Ronconi, Luca (2017). Vitamin b12-metal conjugates for targeted chemotherapy and diagnosis: current status and future prospects. European Journal of Inorganic Chemistry (12), 1625-1638
Abstract
Vitamin B-12 (cyanocobalamin) is a vital nutrient characterized by very low bioavailability. Owing to their extremely high proliferation rates, tumor cells show increased demand for nutrients in comparison with healthy ones, including the greater uptake of vitamin B-12. This avidity for cyanocobalamin can thus be exploited for the site-specific delivery of drugs directly into tumor cells by conjugation of vitamin B-12 (carrier) to either chemotherapeutic or diagnostic agents. In particular, tailored cobalamin-containing substrates can be conjugated to metal-based drugs to achieve targeted delivery into the affected tissues, thus accomplishing biomolecular recognition and tumor selectivity. Progress in the development of metalvitamin B-12 conjugates for medicinal applications is summarized and discussed.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
10.1002/ejic.201601217
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland