Publication

Esperanto for histones: cenp-a, not cenh3, is the centromeric histone h3 variant

Earnshaw, W. C.
; 
Allshire, R. C.
; 
Black, B. E.
; 
Bloom, K.
; 
Brinkley, B. R.
; 
Brown, W.
; 
Cheeseman, I. M.
; 
Choo, K. H. A.
; 
Copenhaver, G. P.
; 
DeLuca, J. G.
... show 10 more
Repository DOI
Publication Date
2013-04-01
Keywords
centromere, cenp-a, histone, kinetochore, cenh3, chromatin, nomenclature, kinetochore, proteins, distinct, complex
Type
Article
Downloads
Show all metadata
Citation
Earnshaw, W. C. Allshire, R. C.; Black, B. E.; Bloom, K.; Brinkley, B. R.; Brown, W.; Cheeseman, I. M.; Choo, K. H. A.; Copenhaver, G. P.; DeLuca, J. G.; Desai, A.; Diekmann, S.; Erhardt, S.; Fitzgerald-Hayes, M.; Foltz, D.; Fukagawa, T.; Gassmann, R.; Gerlich, D. W.; Glover, D. M.; Gorbsky, G. J.; Harrison, S. C.; Heun, P.; Hirota, T.; Jansen, L. E. T.; Karpen, G.; Kops, G. J. P. L.; Lampson, M. A.; Lens, S. M.; Losada, A.; Luger, K.; Maiato, H.; Maddox, P. S.; Margolis, R. L.; Masumoto, H.; McAinsh, A. D.; Mellone, B. G.; Meraldi, P.; Musacchio, A.; Oegema, K.; O’Neill, R. J.; Salmon, E. D.; Scott, K. C.; Straight, A. F.; Stukenberg, P. T.; Sullivan, B. A.; Sullivan, K. F.; Sunkel, C. E.; Swedlow, J. R.; Walczak, C. E.; Warburton, P. E.; Westermann, S.; Willard, H. F.; Wordeman, L.; Yanagida, M.; Yen, T. J.; Yoda, K.; Cleveland, D. W. (2013). Esperanto for histones: cenp-a, not cenh3, is the centromeric histone h3 variant. Chromosome Research 21 (2), 101-106
Abstract
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been suggested to rename this protein CenH3. Here, we argue that the original name should be maintained both because it is the basis of a long established nomenclature for centromere proteins and because it avoids confusion due to the presence of canonical histone H3 at centromeres.
Funder
Publisher
Springer Nature
Publisher DOI
10.1007/s10577-013-9347-y
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
Collections
Externally hosted open access publications with University of Galway authors (2)