Publication

Is coeliac disease a potentially treatable cause of liver failure?

Stevens, Fiona M.
McLoughlin, Ramona M.
Repository DOI
Publication Date
2005-10-01
Type
Article
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Citation
Stevens, Fiona M. McLoughlin, Ramona M. (2005). Is coeliac disease a potentially treatable cause of liver failure?. European Journal of Gastroenterology & Hepatology 17 (10), 1015-1017
Abstract
Hypertransaminasaemia occurs in up to 40% of patients with coeliac disease and resolves with a gluten-free diet. Chronic liver disease such as primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and chronic autoimmune hepatitis is associated with coeliac disease. Coeliac disease is up to 10 times more frequent among patients with chronic liver disease than the general population. Increased intestinal permeability, small intestinal bacterial overgrowth, Kupffer cell abnormalities, direct toxicity of gliadin peptides, or a gliadin-stimulated immunopathological process may have a role to play in the progression of chronic liver disease among coeliac patients. The institution of a gluten-free diet leads to an improvement in those patients with liver failure and previously undiagnosed coeliac disease.
Funder
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
10.1097/00042737-200510000-00002
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland