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Anthelmintic-resistant nematodes in irish commercial sheep flocks- the state of play

Good, Barbara
; 
Hanrahan, James Patrick
; 
de Waal, Daniel Theodorus
; 
Patten, Thomas
; 
Kinsella, Andrew
; 
Lynch, Ciaran Oliver
Identifiers
http://hdl.handle.net/10379/11693
https://doi.org/10.13025/26446
Repository DOI
10.1186/2046-0481-65-21
Publication Date
2012-01-01
Keywords
anthelmintic resistance, nematodes, sheep ireland, benzimidazole, levamizole, ivermectin, maldt, fecrt, veterinary importance
Type
Article
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Citation
Good, Barbara; Hanrahan, James Patrick; de Waal, Daniel Theodorus; Patten, Thomas; Kinsella, Andrew; Lynch, Ciaran Oliver (2012). Anthelmintic-resistant nematodes in irish commercial sheep flocks- the state of play. Irish Veterinary Journal 65 ,
Abstract
Anthelmintic resistance has been reported in most sheep producing countries. Prior to the mid 1990s, reports of anthelmintic resistance in Ireland were sparse and focused on benzimidazole, one of the three classes of anthelmintic available during this period. This evidence for efficacy issues on Irish farms combined with awareness that anthelmintic resistance was increasingly being reported in other countries prompted the need for more comprehensive investigations on Irish farms. Faecal egg count reduction and micro-agar larval development tests were employed to investigate resistance to benzimidazole, levamisole and macrocyclic lactone. There is compelling evidence for resistance to both benzimidazole (>88% of flocks) and levamisole (>39% of flocks). Resistance of nematode populations to macrocyclic lactone was suspected on a small number of farms (11%) but needs to be confirmed. The recent introduction of two new classes of anthelmintics, after over a 25 year interval, together with the evidence that anthelmintic resistance is reported within a relatively short time following the introduction of a new anthelmintic compound means that the challenge to the industry is immediate. Actions are urgently required to manage anthelmintic resistance so as to prolong the lifespan of anthelmintics.
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Publisher
Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)