A replenishable peritoneal implant for localized  delivery and peritoneal fluid sampling in ovarian  cancer

Sheedy, Aoibhin M., Shetty, Mihir, Weis, Anna, Bendzick, Laura E., Stenger, Terran, Ni, Zhenya, et al. (2026). A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer. Device, 101050. https://doi.org/10.1016/j.device.2026.101050

Abstract

Intraperitoneal (i.p.) therapy improves outcomes in abdominal cancers but remains underutilized due to complications from repurposed catheters. In this work, we present a replenishable therapeutic implant for repeated, localized delivery of therapies to the peritoneal cavity. In an ovarian cancer mouse model, expanded natural killer (eNK) cells were delivered once weekly and interleukin-15 (IL-15) thrice weekly. This regime reduced tumor burden compared to standard i.p. injection. The implant supports co-administration of chemotherapy, cytokines, monoclonal antibodies, or other protein-based therapies. Negative pressure applied via the port enabled longitudinal sampling of peritoneal fluid without additional surgical intervention. By reducing procedural burden and improving adaptability, the implant can help increase patient retention and therapeutic efficacy in ovarian cancer and other intra-abdominal cancers.

Funder

Research Ireland
European Union
Massachusetts Institute of Technology

Publisher

Cell Press

Rights

CC BY

cb

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