Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment
Mohr, Andrea Deedigan, Laura Jencz, Sylwia Mehrabadi, Yasamin Houlden, Lily Albarenque, Stella-Maris Zwacka, Ralf M
Mohr, Andrea
Deedigan, Laura
Jencz, Sylwia
Mehrabadi, Yasamin
Houlden, Lily
Albarenque, Stella-Maris
Zwacka, Ralf M
Identifiers
http://hdl.handle.net/10379/12929
https://doi.org/10.13025/26620
https://doi.org/10.13025/26620
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Publication Date
2017-11-03
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Article
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Mohr, Andrea; Deedigan, Laura; Jencz, Sylwia; Mehrabadi, Yasamin; Houlden, Lily; Albarenque, Stella-Maris; Zwacka, Ralf M (2017). Caspase-10: a molecular switch from cell-autonomous apoptosis to communal cell death in response to chemotherapeutic drug treatment. Cell Death and Differentiation 25 (2), 340-352
Abstract
The mechanisms of how chemotherapeutic drugs lead to cell cycle checkpoint regulation and DNA damage repair are well understood, but how such signals are transmitted to the cellular apoptosis machinery is less clear. We identified a novel apoptosis-inducing complex, we termed FADDosome, which is driven by ATR-dependent caspase-10 upregulation. During FADDosome-induced apoptosis, cFLIP(L) is ubiquitinated by TRAF2, leading to its degradation and subsequent FADD-dependent caspase-8 activation. Cancer cells lacking caspase-10, TRAF2 or ATR switch from this cell-autonomous suicide to a more effective, autocrine/paracrine mode of apoptosis initiated by a different complex, the FLIPosome. It leads to processing of cFLIP(L) to cFLIP(p43), TNF-alpha production and consequently, contrary to the FADDosome, p53-independent apoptosis. Thus, targeting the molecular levers that switch between these mechanisms can increase efficacy of treatment and overcome resistance in cancer cells.
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Publisher
Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland