Publication

Invariant natural killer t cells and their ligands: focus on multiple sclerosis

O'Keeffe, Joan
; 
Podbielska, Maria
; 
Hogan, Edward L.
Identifiers
http://hdl.handle.net/10379/13272
 https://doi.org/10.13025/26621
Publication Date
2015-06-25
Keywords
autoimmunity, human, innate lymphoid cells, neuroimmunology, nkt cells, alpha-galactosylceramide, glycolipid antigens, mediated activation, cd1d recognition, danger signals, cutting edge, innate, self, receptors
Type
Article
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Citation
O'Keeffe, Joan; Podbielska, Maria; Hogan, Edward L. (2015). Invariant natural killer t cells and their ligands: focus on multiple sclerosis. Immunology 145 (4), 468-475
Abstract
Invariant natural killer T (iNKT) cells are an innate population of T cells identified by the expression of an invariant T-cell receptor and reactivity to lipid-based antigens complexed with CD1d. They account for a small percentage of lymphocytes, but are extremely potent and play central roles in immunity to infection, in some cancers, and in autoimmunity. The list of relevant stimulatory lipids and glycolipid antigens now includes a range of endogenous self-antigens including the myelin-derived acetylated galactosylceramides. Recent progress in studies to identify the nature of lipid recognition for iNKT cells in autoimmune diseases like multiple sclerosis is likely to foster the development of therapeutic strategies aimed at harnessing iNKT cell activity.
Funder
Publisher
Wiley-Blackwell
Publisher DOI
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (2)