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Ritonavir‐boosted atazanavir, methadone, and ventricular tachycardia: 2 case reports

Gallagher, David P.
; 
Kieran, Jennifer
; 
Sheehan, Gerard
; 
Lambert, John
; 
Mahon, Niall
; 
Mallon, Patrick W. G.
Identifiers
http://hdl.handle.net/10379/11574
 https://doi.org/10.13025/26707
Publication Date
2008-08-01
Keywords
torsades-de-pointes, qt interval
Type
Article
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Citation
Gallagher, David P. Kieran, Jennifer; Sheehan, Gerard; Lambert, John; Mahon, Niall; Mallon, Patrick W. G. (2008). Ritonavir‐boosted atazanavir, methadone, and ventricular tachycardia: 2 case reports. Clinical Infectious Diseases 47 (3), E36-E38
Abstract
We describe 2 cases of symptomatic ventricular tachycardia associated with prolonged QT interval. Both patients were infected with the human immunodeficiency virus and were receiving treatment with ritonavir-boosted atazanavir and methadone. Discontinuation of atazanavir in both cases resulted in a reduction in the QT interval and cessation of arrhythmia. We concluded that atazanavir contributed to prolonged corrected QT interval and subsequent ventricular tachycardia.
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Publisher
Oxford University Press (OUP)
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)