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Angiogenesis inhibitor therapies for advanced renal cell carcinoma: toxicity and treatment patterns in clinical practice from a global medical chart review

OH, WILLIAM K.
; 
McDERMOTT, DAVID
; 
PORTA, CAMILLO
; 
LEVY, ANTONIN
; 
ELAIDI, REZA
; 
SCOTTE, FLORIAN
; 
HAWKINS, ROBERT
; 
CASTELLANO, DANIEL
; 
BELLMUNT, JOAQUIM
; 
RHA, SUN YOUNG
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Identifiers
http://hdl.handle.net/10379/13337
https://doi.org/10.13025/26779
Repository DOI
10.3892/ijo.2013.2181
Publication Date
2013-11-15
Keywords
renal cell carcinoma, angiogenesis inhibitors, safety, treatment patterns, interruption, dose reduction, treatment outcomes, safety, sunitinib, efficacy, sorafenib, cancer, trial, experience, survival
Type
Article
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Citation
OH, WILLIAM K. McDERMOTT, DAVID; PORTA, CAMILLO; LEVY, ANTONIN; ELAIDI, REZA; SCOTTE, FLORIAN; HAWKINS, ROBERT; CASTELLANO, DANIEL; BELLMUNT, JOAQUIM; RHA, SUN YOUNG; SUN, JONG-MU; NATHAN, PAUL; FEINBERG, BRUCE A.; SCOTT, JEFFREY; McDERMOTT, RAY; AHN, JIN-HEE; WAGSTAFF, JOHN; CHANG, YEN-HWA; OU, YEN-CHUAN; DONNELLAN, PAUL; HUANG, CHAO-YUAN; McCAFFREY, JOHN; CHIANG, PO-HUI; CHUANG, CHENG-KENG; KORVES, CAROLINE; NEARY, MAUREEN P.; DIAZ, JOSE R.; MEHMUD, FAISAL; DUH, MEI SHENG (2013). Angiogenesis inhibitor therapies for advanced renal cell carcinoma: toxicity and treatment patterns in clinical practice from a global medical chart review. International Journal of Oncology 44 (1), 5-16
Abstract
The aim of this study was to assess the treatment patterns and safety of sunitinib, sorafenib and bevacizumab in real-world clinical settings in US, Europe and Asia. Medical records were abstracted at 18 community oncology clinics in the US and at 21 tertiary oncology centers in US, Europe and Asia for 883 patients 18 years who had histologically/cytologically confirmed diagnosis of advanced RCC and received sunitinib (n=631), sorafenib (n=207) or bevacizumab (n=45) as first-line treatment. No prior treatment was permitted. Data were collected on all adverse events (AEs) and treatment modifications, including discontinuation, interruption and dose reduction. Treatment duration was estimated using Kaplan-Meier analysis. Demographics were similar across treatment groups and regions. Median treatment duration ranged from 6.1 to 10.7 months, 5.1 to 8.5 months and 7.5 to 9.8 months for sunitinib, sorafenib and bevacizumab patients, respectively. Grade 3/4 AEs were experienced by 26.0, 28.0 and 15.6% of sunitinib, sorafenib and bevacizumab patients, respectively. Treatment discontinuations occurred in 62.4 (Asia) to 63.1% (US) sunitinib, 68.8 (Asia) to 90.0% (Europe) sorafenib, and 66.7 (Asia) to 81.8% (US) bevacizumab patients. Globally, treatment modifications due to AEs occurred in 55.1, 54.2 and 50.0% sunitinib, sorafenib and bevacizumab patients, respectively. This study in a large, global cohort of advanced RCC patients found that angiogenesis inhibitors are associated with high rates of AEs and treatment modifications. Findings suggest an unmet need for more tolerable agents for RCC treatment.
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Publisher
Spandidos Publications
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)