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Conversion of gel-forming crystal needles to easily processable more equant crystals Using high-shear ultralow attrition agitation: accelerated Ostwald ripening without crystal attrition

Civati, Francesco
Erxleben, Andrea
Kellehan, Seamus
McArdle, Patrick
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Publication Date
2019-02-01
Type
Article
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Citation
Civati, Francesco, Erxleben, Andrea, Kellehan, Seamus, & McArdle, Patrick. (2019). Conversion of Gel-Forming Crystal Needles To Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition. Crystal Growth & Design, 19(3), 1502-1504. doi: 10.1021/acs.cgd.8b01650
Abstract
We demonstrate the first examples of the transformation of gel-forming crystal needles into easily processable more equant crystals by accelerated Ostwald ripening without detectable crystal attrition. Using high solution shearing to accelerate mass transfer, diflunisal and isonicotinohydrazide gels are transformed into easily filterable crystals. High-shear ultralow attrition agitation conditions are generated by spinning with rapid reversal of the spinning direction every three seconds.
Publisher
American Chemical Society
Publisher DOI
10.1021/acs.cgd.8b01650
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Attribution-NonCommercial-NoDerivs 3.0 Ireland