Publication

High nuclearity carbonyl clusters as near-ir contrast agents for photoacoustic in vivo imaging

Lam, Zhiyong
; 
Balasundaram, Ghayathri
; 
Kong, Kien Voon
; 
Chor, Bo Yang
; 
Goh, Douglas
; 
Khezri, Bahareh
; 
Webster, Richard D.
; 
Leong, Weng Kee
; 
Olivo, Malini
Identifiers
http://hdl.handle.net/10379/12368
 https://doi.org/10.13025/26794
Publication Date
2016-01-01
Keywords
indocyanine green, optoacoustic tomography, monoxide, microscopy, nanoparticles, mechanisms, molecules, rats, gas
Type
Article
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Citation
Lam, Zhiyong; Balasundaram, Ghayathri; Kong, Kien Voon; Chor, Bo Yang; Goh, Douglas; Khezri, Bahareh; Webster, Richard D. Leong, Weng Kee; Olivo, Malini (2016). High nuclearity carbonyl clusters as near-ir contrast agents for photoacoustic in vivo imaging. J. Mater. Chem. B 4 (22), 3886-3891
Abstract
High nuclearity carbonyl clusters of ruthenium and osmium are found to exhibit good photoacoustic (PA) activity in the near-IR (NIR) region. Their potential as PA contrast agents for full body imaging has been demonstrated for the first time with mice; intravenous administration of the osmium carbonyl cluster Na-2[Os-10(mu(6)-C)(CO)(24)] afforded up to a four-fold enhancement of the PA signal in various tissues. The cluster exhibits low toxicity, high stability and superior PA stability compared to the clinically approved NIR dye, indocyanine green.
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Publisher
Royal Society of Chemistry (RSC)
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
cbn
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Externally hosted open access publications with University of Galway authors (2)