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When one cell is enough

Ceredig, Rhodri
Identifiers
http://hdl.handle.net/10379/10732
 https://doi.org/10.13025/26797
Publication Date
2012-01-01
Keywords
hematopoietic stem-cells, mice
Type
Article
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Citation
Ceredig, Rhodri (2012). When one cell is enough. Stem Cell Research & Therapy 3 ,
Abstract
For many years, the hematopoietic stem cell (HSC) has been well characterized in mice as a cell that can singly reconstitute the whole hematopoietic system of primary recipient animals as well as that of secondary hosts. That clinical bone marrow transplantation is a successful treatment strategy is indirect evidence that such a cell exists in humans. To date, similar criteria have not been applied to human HSCs. However, using a humanized mouse model of xenotransplantation, a recent paper shows that single human cells can fully reconstitute the lymphomyeloid system of primary recipient animals and, in some cases, that of secondary hosts.
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Publisher
Springer Nature
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
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Externally hosted open access publications with University of Galway authors (2)