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Design, synthesis and evaluation of glycomimetics as galectin inhibitors

Dhara, Ashis
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Ashis Dhara Final PhD Thesis.pdf
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Identifiers
http://hdl.handle.net/10379/18086
 https://doi.org/10.13025/16836
Publication Date
2024-03-11
Keywords
Science and Engineering, Biological and Chemical Sciences, Chemistry, Glycomimetics, Galectin Inhibitors
Type
Thesis
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Abstract
Chapter-1: This chapter begins with a short review on carbohydrates and their structure and then summarises some highlights from the last two decades of research on developing carbohydrate-based drug candidates. Included is a summary of the conformational preferences of glycosidic linkages such as, lactose (O-glycosidic linkage). This chapter includes an introduction to C-glycosides and the concept of conformational constraint, which is one approach to glycomimetic design investigated in this thesis work. Also mentioned in Chapter 1 is the structure and biological function of galectins (Gals) and their role in diseases. Furthermore, a review of natural and glycomimetic ligands for galectins is included, with a summary of their binding affinities.
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Publisher
NUI Galway
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Attribution-NonCommercial-NoDerivs 3.0 Ireland
CC BY-NC-ND 3.0 IE
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University of Galway Theses (PhD Theses)