Immunogenomics of gastrointestinal nematode infection in ruminants - breeding for resistance to produce food sustainably and safely
Sweeney, T. Hanrahan, J. P. Ryan, M. T. Good, B.
Sweeney, T.
Hanrahan, J. P.
Ryan, M. T.
Good, B.
Publication Date
2016-09-01
Keywords
gastrointestinal nematodes, genetic selection, immunogenomics, quantitative trait loci, fecal egg counts, ostertagia-circumcincta infection, genome-wide association, internal parasite resistance, scottish blackface lambs, texel sheep breeds, teladorsagia-circumcincta, haemonchus-contortus, anthelmintic resistance
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Article
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Citation
Sweeney, T. Hanrahan, J. P.; Ryan, M. T.; Good, B. (2016). Immunogenomics of gastrointestinal nematode infection in ruminants - breeding for resistance to produce food sustainably and safely. Parasite Immunology 38 (9), 569-586
Abstract
Gastrointestinal nematode (GIN) infection of ruminants represents a major health and welfare challenge for livestock producers worldwide. The emergence of anthelmintic resistance in important GIN species and the associated animal welfare concerns have stimulated interest in the development of alternative and more sustainable strategies aimed at the effective management of the impact of GINs. These integrative strategies include selective breeding using genetic/genomic tools, grazing management, biological control, nutritional supplementation, vaccination and targeted selective treatment. In this review, the logic of selecting for resistance to GIN infection as opposed to resilience or tolerance is discussed. This is followed by a review of the potential application of immunogenomics to genetic selection for animals that have the capacity to withstand the impact of GIN infection. Advances in relevant genomic technologies are highlighted together with how these tools can be advanced to support the integration of immunogenomic information into ruminant breeding programmes.
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Publisher
Wiley-Blackwell
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Attribution-NonCommercial-NoDerivs 3.0 Ireland