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Cardioneuroablation using epicardial pulsed field ablation for the treatment of atrial fibrillation

O’Brien, Barry
; 
Reilly, John
; 
Coffey, Ken
; 
González-Suárez, Ana
; 
Quinlan, Leo
; 
van Zyl, Martin
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Publication Date
2023-05-29
Keywords
atrial fibrillation, ganglionated plexi, cardiac autonomics, cardioneuroablation, pulsed electric field
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Article
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O’Brien, Barry, Reilly, John, Coffey, Ken, González-Suárez, Ana, Quinlan, Leo, & van Zyl, Martin. (2023). Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation. Journal of Cardiovascular Development and Disease, 10(6). doi:10.3390/jcdd10060238
Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and propagation of AF. This paper reviews the background and development of a unique cardioneuroablation technique for the modulation of the cardiac ANS as a potential treatment for AF. The treatment uses pulsed electric field energy to selectively electroporate ANS structures on the epicardial surface of the heart. Insights from in vitro studies and electric field models are presented as well as data from both pre-clinical and early clinical studies.
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Publisher
MDPI
Publisher DOI
10.3390/jcdd10060238
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Attribution 4.0 International (CC BY 4.0)
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Medicine (Scholarly Articles)