Cardioneuroablation using epicardial pulsed field ablation for the treatment of atrial fibrillation

O’Brien, Barry
Reilly, John
Coffey, Ken
González-Suárez, Ana
Quinlan, Leo
van Zyl, Martin
O’Brien, Barry, Reilly, John, Coffey, Ken, González-Suárez, Ana, Quinlan, Leo, & van Zyl, Martin. (2023). Cardioneuroablation Using Epicardial Pulsed Field Ablation for the Treatment of Atrial Fibrillation. Journal of Cardiovascular Development and Disease, 10(6). doi:10.3390/jcdd10060238
Atrial fibrillation (AF) is the most common cardiac arrhythmia affecting millions of people worldwide. The cardiac autonomic nervous system (ANS) is widely recognized as playing a key role in both the initiation and propagation of AF. This paper reviews the background and development of a unique cardioneuroablation technique for the modulation of the cardiac ANS as a potential treatment for AF. The treatment uses pulsed electric field energy to selectively electroporate ANS structures on the epicardial surface of the heart. Insights from in vitro studies and electric field models are presented as well as data from both pre-clinical and early clinical studies.
Publisher DOI
Attribution 4.0 International (CC BY 4.0)