Drug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi
Bansode, Vijay Drebert, Zuzanna J. Travers, Simon A.A. Banda, Emmanuel Molesworth, Anna Crampin, Amelia Ngwira, Bagrey French, Neil Glynn, Judith R. McCormack, Grace P.
Bansode, Vijay
Drebert, Zuzanna J.
Travers, Simon A.A.
Banda, Emmanuel
Molesworth, Anna
Crampin, Amelia
Ngwira, Bagrey
French, Neil
Glynn, Judith R.
McCormack, Grace P.
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Publication Date
2011-04-01
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Article
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Bansode, Vijay; Drebert, Zuzanna J. Travers, Simon A.A.; Banda, Emmanuel; Molesworth, Anna; Crampin, Amelia; Ngwira, Bagrey; French, Neil; Glynn, Judith R.; McCormack, Grace P. (2011). Drug resistance mutations in drug-naive hiv type 1 subtype c-infected individuals from rural malawi. AIDS Research and Human Retroviruses 27 (4), 439-444
Abstract
In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major and minor drug resistance mutations (DRMs). From a sample size of 40 reverse transcriptase (RT) consensus sequences from drug-naive individuals we found five showing NRTI and four showing NNRTI mutations with one individual showing both. From 29 protease consensus sequences, again from drug-naive individuals, we found evidence of minor DRMs in three. Additional major and minor DRMs were found in clonal sequences from a number of individuals that were not present in the original consensus sequences. This clearly illustrates the importance of sequencing multiple HIV-1 variants from individuals to fully assess drug resistance.
Funder
Publisher
Mary Ann Liebert Inc
Publisher DOI
10.1089/aid.2010.0203
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Attribution-NonCommercial-NoDerivs 3.0 Ireland