Publication

Decorated macrocycles via ring-closing double-reductive amination. Identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor

Zhou, Jian
Reidy, Mairead
O'Reilly, Ciaran
Jarikote, Dilip V.
Negi, Arvind
Samali, Afshin
Szegezdi, Eva
Murphy, Paul V.
Citation
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675.
Abstract
A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.
Funder
Publisher
American Chemical Society
Publisher DOI
10.1021/acs.orglett.5b00404
Rights
Attribution-NonCommercial-NoDerivs 3.0 Ireland